Hepatosplenic T-Cell Lymphoma Mimicking Acute Onset of Cholestatic Hepatitis in a Young Immunocompetent Man: A Case Report

We herein report a case of hepatosplenic T-cell lymphoma (HSTCL) incidentally found in 30-year-old man who came to the emergency department after an ankle trauma. At admission, laboratory tests revealed abnormal liver enzymes and pancytopenia, imaging showed mild hepatosplenomegaly. During hospitalization, patient’s clinical condition worsened rapidly, with concomitant increase cholestatic enzymes, severe jaundice, worsening pancytopenia. Causes injury, including many infectious diseases, were explored until diagnosis HSTCL was made by bone marrow biopsies. Subsequently, patient underwent six cycles chemotherapy CHOP (cyclophosphamide, hydroxydaunorubicin, oncovin prednisone or prednisolone) regimen one Hyper-CVAD (fractionated cyclophosphamide, vincristine, doxorubicin, dexamethasone) but, despite this aggressive treatment, died due disease progression 2 months diagnosis. This rare should be considered diagnostic workup acute hepatitis presenting hepatosplenomegaly cytopenia.